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KMID : 0358419740170100611
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Korean Journal of Obstetrics and Gynecology
1974 Volume.17 No. 10 p.611 ~ p.615
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Choriocarcinoma Associated with Pregnancy
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李富順/Lee, Boo Soon
朴永洙/朱英哲/柳泰淑/Park, Yung Joo/Joo, Young Chull/Yoo, Tae Sook
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Abstract
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The case to be reported is unusual interesting patient because of coexisting metastatic chorioczucinoma and pregnancy.
A 32 year old multigravida had genital bleeding from vulvar metastatic lesion of choriocarcinoma at 32 gestational week. During the 1st admission cesarean section and tubal ligation were performed and a living female baby weighing 1,700 gm was delivered. Two courses of
methotrexate (12 5mg/day, 72.5mg/course) treatment were done without. notable side effect sand patient was discharged with complete remission of trophoblastic tumor. During the 2nd .admission total abdominal hysterectomy, left salpingo oophorectomy and right salpingectomy wore, performed and possible primaryy lesion of choriocarcinoma was found at the midposterior ,aspect of uterine cavity. After total 4 courses of methotrexate(72.5mg-l00mg/course) treatment without remarkable side effect, patient was discharged with partial remission of trophoblastic-tumor. Chest lesions still remained but vulvar metastatic lesion disappeared completely. The :patient was readmitted due to severe headache and limitation of extension of the right elbow .and knee. Skull-x-ray showed several small bean sized metastatic lesions in the skull-vault. Left carotid angiography revealed possible brain metastasis from choriocarcinoma, which was disclosed by autopsy later on.In spite of additional 7th -´& 8th course of methotrexate (37.5mg-75mg/each course) and: 6 mercaptopurine (40 -mg x 3 for 3´ days) treatments the patient´s condition had getting worse. sand finally, the patient expired on Feb. 19, 1973.
Literatures are briefly reviewed.
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